ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF DECALEPIS HAMILTONII LEAVES EXTRACT

In most nations, diabetes mellitus is a serious and rising health issue. The goal of the study was to compare antidiabetic effects leaves extracts Decalepis hamiltonii in normal diabetic rats induced with alloxan. Using 120 mg/kg alloxan monohydrate, induced. order considerably lower blood glucose levels both alloxan-induced rats, D. methanolic extract given at doses 200 mg 400 mg, along glibenclamide dose 7 bwt. Additionally, injection dramatically reduced AST, ALT, triglycerides, total cholesterol while simultaneously raising amount liver glycogen. perform oral tolerance test (OGTT), separate groups were (200 mg), (7.5 which effectively sugar following an load all time points. These findings indicate that rats' successfully lowered by leaves. antioxidant potential measured using various vitro assays. showed high activity as scavenging DPPH, superoxide hydroxyl radicals. did not correlate phenolic content extracts. results demonstrate potency could be basis for its alleged promoting hamiltonii. serve new source natural antioxidants or nutraceuticals applications reducing level oxidative stress related benefits. KEYWORDS: hamiltonii, Antidiabetic, Antioxidant, Alloxan, OGTT